Letitia Tyler (1790-1842) was an American first lady (1841-1842) and the first wife of John Tyler, the 10th president of the United States. Two years before her husband assumed the presidency, Letitia suffered a debilitating stroke. As a result, she spent her entire tenure as first lady in a semi-invalid state, attending only one public function. She passed away in September 1842, the first first lady to die in the White House. Two years later, her widowed husband married the young socialite Julia Gardiner.